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“The Pertussis vaccine itself was awarded a big part in this ongoing drama when, in 1959, it was found to have a particularly powerful allergenic effect on all sorts of laboratory animals. Experiments to produce anaphylactic shock are facilitated by addition of pertussis vaccine to the solution: the mice (or rabbits, or hamsters, or whatever) die more rapidly, and in larger numbers. By the same token, addition of the vaccine to the sterile brain and spinal cord solution greatly enhances it's ability to generate an allergic encephalitis. For these reasons pertussis vaccine is the preferred "adjuvant" in experiments to produce allergic encephalomyelitis.” — Harris Coulter
The Pertussis vaccine itself was awarded a big part in this ongoing drama when, in 1959, it was found to have a particularly powerful allergenic effect on all sorts of laboratory animals. Experiments to produce anaphylactic shock are facilitated by addition of pertussis vaccine to the solution: the mice (or rabbits, or hamsters, or whatever) die more rapidly, and in larger numbers. By the same token, addition of the vaccine to the sterile brain and spinal cord solution greatly enhances it's ability to generate an allergic encephalitis. For these reasons pertussis vaccine is the preferred "adjuvant" in experiments to produce allergic encephalomyelitis.