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“What accounts for this great diversity running through our veins? The struggle for survival entails not only the competition for resources and mates but also the battle against pathogens. In this immunological arms race, the blood group antigens of human populations have coevolved with a microscopic world of enemies (as well as allies and neutral parties). Natural selection shapes the human immune system by favoring the configurations best adapted to a population's environment.” — Avi Tuschman

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What accounts for this great diversity running through our veins? The struggle for survival entails not only the competition for resources and mates but also the battle against pathogens. In this immunological arms race, the blood group antigens of human populations have coevolved with a microscopic world of enemies (as well as allies and neutral parties). Natural selection shapes the human immune system by favoring the configurations best adapted to a population's environment.
— Avi Tuschman