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“The starting point is recognizing that selection has shaped powerful mechanisms to protect against starvation. During a famine, those mechanisms motivate animals to get food -any food- eat it quickly, and eat more than usual, because food supplies are obviously erratic. The system also adjusts the body weight set point upward because extra fat stores are valuable when food sources are unreliable. And, as noted already, weight loss slows down metabolism, which is appropriate when a person is starving but the opposite of what is needed when trying to lose weight. Also, intermittent access to food signals unreliable access to food supplies, so it increases food intake and bingeing, even in rats.” — Randolph M. Nesse

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The starting point is recognizing that selection has shaped powerful mechanisms to protect against starvation. During a famine, those mechanisms motivate animals to get food -any food- eat it quickly, and eat more than usual, because food supplies are obviously erratic. The system also adjusts the body weight set point upward because extra fat stores are valuable when food sources are unreliable. And, as noted already, weight loss slows down metabolism, which is appropriate when a person is starving but the opposite of what is needed when trying to lose weight. Also, intermittent access to food signals unreliable access to food supplies, so it increases food intake and bingeing, even in rats.
— Randolph M. Nesse