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“For many years, it was believed that the connections between neurons in an adult brain were fixed. Learning, it was believed, involved increasing or decreasing the strength of synapses. This is still how learning occurs in most artificial neural networks. However, over the past few decades, scientists have discovered that in many parts of the brain, including the neocortex, new synapses form and old ones disappear. Every day, many of the synapses on an individual neuron will disappear and new ones will replace them. Thus, much of learning occurs by forming new connections between neurons that were previously not connected. Forgetting happens when old or unused connections are removed entirely.” — Jeff Hawkins

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For many years, it was believed that the connections between neurons in an adult brain were fixed. Learning, it was believed, involved increasing or decreasing the strength of synapses. This is still how learning occurs in most artificial neural networks. However, over the past few decades, scientists have discovered that in many parts of the brain, including the neocortex, new synapses form and old ones disappear. Every day, many of the synapses on an individual neuron will disappear and new ones will replace them. Thus, much of learning occurs by forming new connections between neurons that were previously not connected. Forgetting happens when old or unused connections are removed entirely.
— Jeff Hawkins