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“For unknown reasons, rare depressed patients even today will respond to no medicine except opiates, and a few researchers into depression have become newly interested in these substances. Fifty years ago, most patients who felt better on opium probably valued it for its ability to ameliorate scattered symptoms, such as sleeplessness, anxiety, and a general sense of malaise. Perhaps for mistaken reasons, Kuhn took the occasional success of opium to set the standard in the search for antidepressants. The hallmark of opium was that it restored energy in the depressed without being inherently energizing. Kuhn set our "to find a drug acting in some specific manner against melancholy that is better than opium"- that is, a nonstimulating antidepressant.” — Peter D. Kramer