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“Given that observable neurobehavioural characteristics in adulthood are determined in part by GABA-A receptors in early life, and the impact of GABA-acting drugs during pregnancy – in particular, on the construction of the brain – have been said to lead to ‘a cascade of pathogenic consequences’, it’s clear that the long-term effects of phenobarbital regularly administered during infancy would be severe.” — Antonella Gambotto-Burke
Given that observable neurobehavioural characteristics in adulthood are determined in part by GABA-A receptors in early life, and the impact of GABA-acting drugs during pregnancy – in particular, on the construction of the brain – have been said to lead to ‘a cascade of pathogenic consequences’, it’s clear that the long-term effects of phenobarbital regularly administered during infancy would be severe.