Mike Patterson (born September 1, 1983) is an American professional football player who played as a defensive tackle in the National Football League (NFL). He was selected by the Philadelphia Eagles in the first round of the 2005 NFL Draft and later played for the New York Giants. Known for his strength and agility on the defensive line, Patterson contributed significantly to his teams' run and pass defense. He is also recognized for overcoming a brain surgery in 2011 to return to the field, demonstrating remarkable resilience. His career includes over 300 tackles and 20 sacks, earning respect as a reliable and tough player.