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Quote by Francis Crick

“It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.”

Quote by Francis Crick

Author

Francis Crick was a renowned scientist known for his significant contributions to the field of molecular biology. He, along with James Watson, was awarded the Nobel Prize in Physiology or Medicine in 1962 for their discovery of the double-helix structure of DNA. Crick's research had a profound impact on understanding the transmission of genetic information and the genetic basis of organisms. more

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“It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.”

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“If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.”

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“The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority.”

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“The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.”

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“How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.”

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“For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.”

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“Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap.”

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“A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.”

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