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Quote by Tom Golway

“Epidemiology is an ever evolving science since predictive models have significant sensitive dependencies on initial assumptions - Tom Golway”

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Tom Golway

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“There is compelling evidence to argue that cells can sense and respond to the stiffness of their ECM and that they transmit these cues to the nucleus to alter their shape and modify their chromatin accessibility either directly or indirectly by modulating cellular metabolism. What has yet to be determined is whether these tension-induced changes in chromatin modification and chromosomal localization are accompanied by specific differences in gene expression and whether altering the metabolic state of the cell could modify these phenotypes. Moreover, whether similar effect occur in fibrotic, stiffened tumor tissues and if this influences gene expression to drive a tumor-like behavior in the cells and tissue remain unclear.”

TensionMetabolismEpigeneticsChromatin
Author:R. Oria, D. Thakar, and V. M. Weaver
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“Epigenetics reveals that your body isn’t a genetically predetermined flesh robot, but is regulated by a set of gene switches that can be turned on or off—by you—mindfully. Ergo, our genes aren’t our destiny. We have far more control over their expression than most ever imagined.”

BiologyGenesDnaGeneticsPower Of Positive ThinkingMind Body ConnectionPlacebo EffectEpigeneticsBiology Of BeliefGenetic Predisposition
Book:Get Out of Here Alive: Inner Alchemy & Immortality
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“In the folklore of science, there is the often-told story of the moment of discovery: the quickening of the pulse, the spectral luminosity of ordinary facts, the overheated, standstill second when observations crystallize and fall together into patterns, like pieces of a kaleidoscope. The apple drops from the tree. The man jumps up from a bathtub; the slippery equation balances itself. But there is another moment of discovery—its antithesis—that is rarely recorded: the discovery of failure. It is a moment that a scientist often encounters alone. A patient’s CT scan shows a relapsed lymphoma. A cell once killed by a drug begins to grow back. A child returns to the NCI with a headache.”

AntithesisEureka Moments
Author:Siddhartha Mukherjee
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