“Vogelstein’s challenge was that of the landscape artist: How does one convey the gestalt of a territory (in this case, the “territory” of a genome) in a few broad strokes of a brush? How can a picture describe the essence of a place?Vogelstein’s answer to these questions borrows beautifully from an insight long familiar to classical landscape artists: negative space can be used to convey expanse, while positive space conveys detail. To view the landscape of the cancer genome panoramically, Vogelstein splayed out the entire human genome as if it were a piece of thread zigzagging across a square sheet of paper. (Science keeps eddying into its past: the word mitosis -- Greek for "thread" -- is resonant herw again.)” MetaphorLandscape PaintingCancer GenomeMitosis Book:The Emperor of All Maladies: A Biography of Cancer Source: The Emperor of All Maladies: A Biography of Cancer