“Few diseases have had an impact on human evolution, culture and society on par with malaria. It is one of the oldest documented infectious diseases. Indeed, it has been hypothesised that the protective effect bestowed by a heterozygous sickle cell allele explains its survival to the modern day. As such, malaria has left its footprint on human evolution in a profound way few other diseases have. Yet its true origins were the matter of considerable controversy. The clue is in the name – the prevailing theory until Ross's discovery was that malaria resulted from 'mala aria', that is, 'bad air'. It took the advent of modern evidence-based medical science to challenge this 'miasma theory'. Ross's elucidation of the role of mosquitoes in the lifecycle of malaria has opened up a new subject for epidemiological consideration: the vector-borne disease.” EvolutionMalariaEpidemiologyCoevolutionMiasma Book:Computational Modeling of Infectious Disease: With Applications in Python Source: Computational Modeling of Infectious Disease: With Applications in Python