“ME is a neuroimmune disease that, contrary to common misconceptions, is not characterised by chronic fatigue, but rather by a severe exacerbation of symptoms which manifest after a minor physical or mental exertion. This hallmark symptom characteristic of ME, known as Post-Exertional Malaise (PEM), can persist for days, weeks or consequently be a the trigger for a relapse or deterioration.” CfsChronic Fatigue SyndromeMyalgic EncephalomyelitisMe CfsMe Cfs QuotesPost Exertional MalaisePem Author:Anil van der Zee