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Quote by Francis Crick

“It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.”

Quote by Francis Crick

Author

Francis Crick was a renowned scientist known for his significant contributions to the field of molecular biology. He, along with James Watson, was awarded the Nobel Prize in Physiology or Medicine in 1962 for their discovery of the double-helix structure of DNA. Crick's research had a profound impact on understanding the transmission of genetic information and the genetic basis of organisms. more

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“It seems likely that most if not all the genetic information in any organism is carried by nucleic acid - usually by DNA, although certain small viruses use RNA as their genetic material.”

Ifs Use Seems Certain Information Materials Organisms Dna Acid Viruses Rna

Author:Francis Crick

“It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.”

May Seems Code Acid Amino Acids Triplet

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“It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.”

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“It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.”

Evidence Direct Method Code Indirect Triplet

Author:Francis Crick

“If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.”

Ifs Doe Evidence Foundation Code Logical Good And Bad

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“The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority.”

May Possibility Raises Observation Code Minorities Unfortunate Acid Ambiguous Unclear Amino Acids Triplet

Author:Francis Crick

“The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.”

Wells May Doe Study Balance Evidence Cells Acid Mutation Amino Acids Triplet

Author:Francis Crick

“How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.”

Shows Groups Bases Divided Sequence Acid Backbone

Author:Francis Crick

“For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.”

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Author:Francis Crick

“Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap.”

Two Seems Certain Members Messages

Author:Francis Crick