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Quote by Frank Twisk

“The diagnostic criteria for myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) define two distinct clinical entities. Cognitive impairment and post-exertional “malaise” (a long-lasting aggravation of typical symptoms, e.g., muscle weakness and cognitive “brain fog”, after minor exertion) are obligatory for the diagnosis ME, while chronic fatigue is the only mandatory symptom for the diagnosis CFS.”

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Frank Twisk

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“Many people confuse “chronic fatigue” (which is a symptom of many chronic conditions, including rheumatoid arthritis, fibromyalgia, or lupus) or “general tiredness” (which is lifestyle-related), with the specific illness “chronic fatigue syndrome” (ME/CFS). To clarify the differences, here are some of the major symptoms of ME/CFS: - unexplained physical and mental fatigue for an extended period of time - post-exertional malaise (meaning an inappropriate loss of physical and mental stamina and a worsening of symptoms after any effort) - sleep dysfunction - pain - neurological/cognitive manifestations - autonomic manifestations, such as orthostatic intolerance - neuroendocrine symptoms, such as subnormal body temperature - immune system changes, such as recurrent flu-like symptoms.”

FatigueChronic Fatigue SyndromeMyalgic EncephalomyelitisM E CfsChronic Fatigue
Author:Valerie free
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“Over the years, I have cared for loved ones with advanced Alzheimer, late stage cardiovascular and renal disease and Stage 4 cancer. But none of those experiences prepared me for being a carer for a Severe or Very Severe ME patient. The breadth, severity and unprediciability of the symptoms and dysfunction from one person ro the next and from one day to the next can be hard to comprehend and mainstream medical education doesn't help.”

CfsChronic Fatigue SyndromeMyalgic EncephalomyelitisM E CfsM E
Book:Severe ME : Notes for Carers
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“The label ‘Chronic Fatigue Syndrome’ was first proposed by Holmes et al. (1988) of the Centers for Disease Control (CDC). This name was recommended to replace that of a number of terms that implied a causal pathology (e.g. ‘Myalgic Encephalomyelitis’, ‘Post-Viral Fatigue Syndrome’ and ‘chronic Epstein-Barr virus syndrome’), as there was a lack of correlation between biological markers and symptomatology. Hence, this new label reflected the prime clinical characteristic of the condition without alluding to an underlying physical aetiology and, in turn, the definition was based upon signs and symptoms of the patient group. However, many individuals use the term Myalgic Encephalomyelitis (indicating muscle pain and inflammation of the brain), a fact that is reflected by the titles of the two largest charitable organisations in the UK, the ME Association and Action for ME.”

CfsChronic Fatigue SyndromeMyalgic EncephalomyelitisM E CfsM E
Author:Megan A. Arroll
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