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“They don't make poles long enough for me want to touch Microsoft products, and I don't want any mass-marketed game-playing device or Windows appliance near my desk or on my network. This is my workbench, dammit, it's not a pretty box to impress people with graphics and sounds. When I work at this system up to 12 hours a day, I'm profoundly uninterested in what user interface a novice user would prefer.”

“Many concerns now make part or the whole of their dividends from by-products that formerly went to waste. How do we, as individuals, utilize our principal by-product? Our principal by-product is, of course, our leisure time. Many years of observation forces the conclusion that a man's success or failure in life is determined as much by how he acts during his leisure as by how he acts during his work hours. Tell me how a young man spends his evenings and I will tell you how he is likely to spend the latter part of his life.”

“[Melinda Gates] is a lot of fun to work with. There's some of the people skills that she's better at and cares about more. It'd be a mistake not to think of her as very numerical and interested in the science. I enjoy, if I get ahead of her, say, understanding the immune system, then we can spend a few hours, where I'm going through how amazing it is and interesting, and how that affects our creating new products, so I've always had a partner.”