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“The dramatic changes that occurred in the relationships between humans and animals as societies transitioned from hunting and foraging to herding and farming, and from living in rural to urban and industrialized environments, had major impacts on pathogen evolution. The development, spread and intensification of agriculture, coupled with urbanization and increased connectivity through trade, enhanced opportunities for pathogens to be shared. Populations of potential hosts, human and animal, were increasingly crowded together often in unsanitary environments. These conditions drove pathogen transmission and virulence because they facilitated transmission from heavily infected and very sick individuals.”

“The factors facilitating the global emergence of pathogens shared between humans and animals are of particular importance because the diseases they induce have had major impacts on both human and animal health. This transfer of pathogens has ocurred for thousands, if not millions, of years and continues today.”

“Our species has co-evolved alongside many others to which we were in contact, especially through scavenging, hunting, and then animal husbandry, all of which would have exposed us to novel pathogens and zoonotic diseases. As a species, we had to adapt to these new pathogens without the benefits of modern medicine. The newly emerging diseases of recent decades, while novel in themselves, are but a repeat of patterns which humans have survived over several millennia.”

“Today there are almost eight billion people on earth, crowded together and travelling widely -this is 1300 times more than were present when the agricultural revolution began around 10,000 years ago and facilitated the spread of many pathogens.”

“Humans have always lived surrounded by potential pathogens. Whether they co-exist relatively harmlessly or become a problem, cause acute or chronic disease and spread slowly or in epidemics has been, and still is, influenced by how we have impacted the environments we share with other animals. Pathogens are opportunists within these environments, capable and ready to take advantage of anything that promotes their transmission.”