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“Indeed, while Nature is wonderfully inventive of new structures, her conservatism in holding on to old ones is still more remarkable. In the ascending line of development she tries an experiment once exceedingly thorough, and then the question is solved for all time. For she always takes time enough to try the experiment exhaustively. It took ages to find how to build a spinal column or brain, but when the experiment was finished she had reason to be, and was, satisfied.”

“An experiment in nature, like a text in the Bible, is capable of different interpretations, according to the preconceptions of the interpreter.”

“It seems to me of great importance to teach children respect for life. Towards this end, experiments on living animals in classrooms should be stopped. To encourage cruelty in the name of science can only destroy the finer emotions of affection and sympathy, and breed an unfeeling callousness in the young towards suffering in all living creatures.”

“Suicide may also be regarded as an experiment - a question which man puts to Nature, trying to force her to answer. The question is this: What change will death produce in a man's existence and in his insight into the nature of things? It is a clumsy experiment to make; for it involves the destruction of the very consciousness which puts the question and awaits the answer.”

“What the scientists have always found by physical experiment was an a priori orderliness of nature, or Universe always operating at an elegance level that made the discovering scientist's working hypotheses seem crude by comparison. The discovered reality made the scientists exploratory work seem relatively disorderly.”

“The more experiences and experiments accumulate in the exploration of nature, the more precarious the theories become. But it is not always good to discard them immediately on this account. For every hypothesis which once was sound was useful for thinking of previous phenomena in the proper interrelations and for keeping them in context. We ought to set down contradictory experiences separately, until enough have accumulated to make building a new structure worthwhile.”

“During the time that [Karl] Landsteiner gave me an education in the field of imununology, I discovered that he and I were thinking about the serologic problem in very different ways. He would ask, What do these experiments force us to believe about the nature of the world? I would ask, What is the most. simple and general picture of the world that we can formulate that is not ruled by these experiments? I realized that medical and biological investigators were not attacking their problems the same way that theoretical physicists do, the way I had been in the habit of doing.”

“I have often had cause to feel that my hands are cleverer than my head. That is a crude way of characterizing the dialectics of experimentation. When it is going well, it is like a quiet conversation with Nature. One asks a question and gets an answer, then one asks the next question and gets the next answer. An experiment is a device to make Nature speak intelligibly. After that, one only has to listen.”

“Only by following out the injunction of our great predecessor [William Harvey] to search out and study the secrets of Nature by way of experiment, can we hope to attain to a comprehension of 'the wisdom of the body and the understanding of the heart,' and thereby to the mastery of disease and pain, which will enable us to relieve the burden of mankind.”