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“Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.”

“I think that we shall have to get accustomed to the idea that we must not look upon science as a 'body of knowledge,' but rather as a system of hypotheses; that is to say, as a system of guesses or anticipations which in principle cannot be justified, but with which we work as long as they stand up to tests, and of which we are never justified in saying that we know they are 'true' or 'more or less certain' or even 'probable.'”

“It is really laughable to see what different ideas are prominent in various naturalists' minds, when they speak of 'species'; in some, resemblance is everything and descent of little weight-in some, resemblance seems to go for nothing, and Creation the reigning idea-in some, descent is the key,-in some, sterility an unfailing test, with others it is not worth a farthing. It all comes, I believe, from trying to define the undefinable.”

“It's becoming clear that in a sense the cosmos provides the only laboratory where sufficiently extreme conditions are ever achieved to test new ideas on particle physics. The energies in the Big Bang were far higher than we can ever achieve on Earth. So by looking at evidence for the Big Bang, and by studying things like neutron stars, we are in effect learning something about fundamental physics.”

“The mathematician's patterns, like the painter's or the poet's must be beautiful; the ideas, like the colours or the words must fit together in a harmonious way. Beauty is the first test: there is no permanent place in the world for ugly mathematics.”

“On May 15, 1957 Linus Pauling made an extraordinary speech to the students of Washington University. ... It was at this time that the idea of the scientists' petition against nuclear weapons tests was born. That evening we discussed it at length after dinner at my house and various ones of those present were scribbling and suggesting paragraphs. But it was Linus Pauling himself who contributed the simple prose of the petition that was much superior to any of the suggestions we were making.”

“In legal parlance, that is called 'the rational person test,' ... That's where somebody else says, 'Even though we have no idea what this person would want in this circumstance in which they cannot themselves tell us what they want, a 'rational' person - meaning, myself - in that circumstance would want to die.' So you move very quickly from so-called voluntary euthanasia to involuntary euthanasia. These legal and medical developments are not simply hypothetical They're in the courts right now.”

“The test of a round character is whether it is capable of surprising in a convincing way. If it never surprises it is flat. Flat characters ... in their purest form ... are constructed round a single idea or quality; when there is more than one factor to them, we get the beginning of the curve toward the round. The really flat character can be experessed in one sentence such as, "I will never desert Mr Micawber." There is Mrs Micawber - she says she won't desert Mr Micawber; she doesn't, and there she is.”

“When I get an idea I start at once building it up in my imagination. I change the construction, make improvements and operate the device in my mind. It is absolutely immaterial to me whether I run my turbine in my thought or test it in my shop. I even note if it is out of balance.”

“Entrepreneurs need to start building today. The barrier to entry in tech is low, so start designing, start coding it, launch it, build prototypes, build a working version of it. The Internet has amazing powers of distribution. You can test your ideas. You can see if it works, if it doesn't work, whether it's fun, and whether you're sufficiently motivated. People who go into entrepreneurship to get rich aren't going to be happy. It’s the building of things that makes you happy. You have to enjoy the process whether you succeed or fail.”