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“Almost all the world is natural chemicals, so it really makes you re-think everything. A cup of coffee is filled with chemicals. They've identified a thousand chemicals in a cup of coffee. But we only found 22 that have been tested in animal cancer tests out of this thousand. And of those, 17 are carcinogens. There are ten milligrams of known carcinogens in a cup of coffee and thats more carcinogens than youre likely to get from pesticide residues for a year!”

“However the machine would permit us to test the hypothesis for any special value of n. We could carry out such tests for a sequence of consecutive values n=2,3,.. up to, say, n=100. If the result of at least one test were negative, the hypothesis would prove to be false; otherwise our confidence in the hypothesis would increase, and we should feel encouraged to attempt establishing the hypothesis, instead of trying to construct a counterexample.”

“We shall do better to abandon the whole attempt to learn the truthunless we can trust to the human mind's having such a powerof guessing right that before very many hypotheses shall have been tried, intelligent guessing may be expected to lead us to one which will support all tests, leaving the vast majority of possible hypotheses unexamined.”

“Savages have often been likened to children, and the comparison is not only correct but also highly instructive. Many naturalists consider that the early condition of the individual indicates that of the race,-that the best test of the affinities of a species are the stages through which it passes. So also it is in the case of man; the life of each individual is an epitome of the history of the race, and the gradual development of the child illustrates that of the species.”

“I know a good many men of great learning-that is, men born with an extraordinary eagerness and capacity to acquire knowledge. One and all, they tell me that they can't recall learning anything of any value in school. All that schoolmasters managed to accomplish with them was to test and determine the amount of knowledge that they had already acquired independently-and not infrequently the determination was made clumsily and inaccurately.”

“There is not enough evidence, consistent evidence to make it as fact, and I say that because for theory to become a fact, it needs to consistently have the same results after it goes through a series of tests. The tests that they put- that they use to support evolution do not have consistent results. Now too many people are blindly accepting evolution as fact. But when you get down to the hard evidence, it's merely a theory.”

“The mathematical framework of quantum theory has passed countless successful tests and is now universally accepted as a consistent and accurate description of all atomic phenomena. The verbal interpretation, on the other hand - i.e., the metaphysics of quantum theory - is on far less solid ground. In fact, in more than forty years physicists have not been able to provide a clear metaphysical model.”

“Man does not limit himself to seeing; he thinks and insists on learning the meaning of phenomena whose existence has been revealed to him by observation. So he reasons, compares facts, puts questions to them, and by the answers which he extracts, tests one by another. This sort of control, by means of reasoning and facts, is what constitutes experiment, properly speaking; and it is the only process that we have for teaching ourselves about the nature of things outside us.”

“We have three approaches at our disposal: the observation of nature, reflection, and experimentation. Observation serves to assemble the data, reflection to synthesise them and experimentation to test the results of the synthesis. The observation of nature must be assiduous, just as reflection must be profound, and experimentation accurate. These three approaches are rarely found together, which explains why creative geniuses are so rare.”

“But when we face the great questions about gravitation Does it require time? Is it polar to the 'outside of the universe' or to anything? Has it any reference to electricity? or does it stand on the very foundation of matter-mass or inertia? then we feel the need of tests, whether they be comets or nebulae or laboratory experiments or bold questions as to the truth of received opinions.”

“Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.”

“I think that we shall have to get accustomed to the idea that we must not look upon science as a 'body of knowledge,' but rather as a system of hypotheses; that is to say, as a system of guesses or anticipations which in principle cannot be justified, but with which we work as long as they stand up to tests, and of which we are never justified in saying that we know they are 'true' or 'more or less certain' or even 'probable.'”

“It is really laughable to see what different ideas are prominent in various naturalists' minds, when they speak of 'species'; in some, resemblance is everything and descent of little weight-in some, resemblance seems to go for nothing, and Creation the reigning idea-in some, descent is the key,-in some, sterility an unfailing test, with others it is not worth a farthing. It all comes, I believe, from trying to define the undefinable.”

“It's becoming clear that in a sense the cosmos provides the only laboratory where sufficiently extreme conditions are ever achieved to test new ideas on particle physics. The energies in the Big Bang were far higher than we can ever achieve on Earth. So by looking at evidence for the Big Bang, and by studying things like neutron stars, we are in effect learning something about fundamental physics.”

“We may discover resources on the moon or Mars that will boggle the imagination, that will test our limits to dream. And the fascination generated by further exploration will inspire our young people to study math, and science, and engineering and create a new generation of innovators and pioneers.”

“All Science is necessarily prophetic, so truly so, that the power of prophecy is the test, the infallible criterion, by which any presumed Science is ascertained to be actually & verily science. The Ptolemaic Astronomy was barely able to prognosticate a lunar eclipse; with Kepler and Newton came Science and Prophecy.”

“Twenty centuries of 'progress' have brought the average citizen a vote, a national anthem, a Ford, a bank account, and a high opinion of himself, but not the capacity to live in high density without befouling and denuding his environment, nor a conviction that such capacity, rather than such density, is the true test of whether he is civilized.”

“The fundamental problem in the origin of species is not the origin of differences in appearance, since these arise at the level of the geographical race, but the origin of genetic segregation. The test of species-formation is whether, when two forms meet, they interbreed and merge, or whether they keep distinct.”

“I therefore took this opportunity and also began to consider the possibility that the Earth moved. Although it seemed an absurd opinion, nevertheless, because I knew that others before me had been granted the liberty of imagining whatever circles they wished to represent the phenomena of the stars, I thought that I likewise would readily be allowed to test whether, by assuming some motion of the Earth's, more dependable representations than theirs could be found for the revolutions of the heavenly spheres.”

“It is easy to obtain confirmations, or verifications, for nearly every theory-if we look for confirmations. Confirmations should count only if they are the result of risky predictions... A theory which is not refutable by any conceivable event is non-scientific. Irrefutability is not a virtue of a theory (as people often think) but a vice. Every genuine test of a theory is an attempt to falsify it, or refute it.”

“All interpretations made by a scientist are hypotheses, and all hypotheses are tentative. They must forever be tested and they must be revised if found to be unsatisfactory. Hence, a change of mind in a scientist, and particularly in a great scientist, is not only not a sign of weakness but rather evidence for continuing attention to the respective problem and an ability to test the hypothesis again and again.”

“Richard Feynman was fond of giving the following advice on how to be a genius. You have to keep a dozen of your favorite problems constantly present in your mind, although by and large they will lay in a dormant state. Every time you hear or read a new trick or a new result, test it against each of your twelve problems to see whether it helps. Every once in a while there will be a hit, and people will say, "How did he do it? He must be a genius!"”

“Every great advance in science has issued from a new audacity of imagination. What are now working conceptions, employed as a matter of course because they have withstood the tests of experiment and have emerged triumphant, were once speculative hypotheses.”

“There is one experiment which I always like to try, because it proves something whichever way it goes. A solution of iodine in water is shaken with bone-black, filtered and tested with starch paste. If the colorless solution does not turn the starch blue, the experiment shows how completely charcoal extracts iodine from aqueous solution. If the starch turns blue, the experiment shows that the solution, though apparently colorless, still contains iodine which can be detected by means of a sensitive starch test.”

“I feel that, in a sense, the writer knows nothing any longer. He has no moral stance. He offers the reader the contents of his own head, a set of options and imaginative alternatives. His role is that of a scientist, whether on safari or in his laboratory, faced with an unknown terrain or subject. All he can do is to devise various hypotheses and test them against the facts.”

“On May 15, 1957 Linus Pauling made an extraordinary speech to the students of Washington University. ... It was at this time that the idea of the scientists' petition against nuclear weapons tests was born. That evening we discussed it at length after dinner at my house and various ones of those present were scribbling and suggesting paragraphs. But it was Linus Pauling himself who contributed the simple prose of the petition that was much superior to any of the suggestions we were making.”

“The day when the scientist, no matter how devoted, may make significant progress alone and without material help is past. This fact is most self-evident in our work. Instead of an attic with a few test tubes, bits of wire and odds and ends, the attack on the atomic nucleus has required the development and construction of great instruments on an engineering scale.”

“It has the property of detonating very violently in certain circumstances. On one occasion a small amount of ether solution of pyroglycerin condensed in a glass bowl. ... When the bowl was heated over a spirit lamp, an extremely violent explosion occurred, which shattered it into small fragments. On another occasion a drop was heated in a test-tube, and exploded with such violence that the glass splinters cut deep into my face and hands, and hurt other people who were standing some distance off in the room.”

“The natural scientist is concerned with a particular kind of phenomena ... he has to confine himself to that which is reproducible ... I do not claim that the reproducible by itself is more important than the unique. But I do claim that the unique exceeds the treatment by scientific method. Indeed it is the aim of this method to find and test natural laws.”