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“No scientist or student of science, need ever read an original work of the past. As a general rule, he does not think of doing so. Rutherford was one of the greatest experimental physicists, but no nuclear scientist today would study his researches of fifty years ago. Their substance has all been infused into the common agreement, the textbooks, the contemporary papers, the living present.”

“The discoveries of science, the works of art are explorations - more, are explosions, of a hidden likeness. The discoverer or artist presents in them two aspects of nature and fuses them into one. This is the act of creation, in which an original thought is born, and it is the same act in original science and original art.”

“Every Man being conscious to himself, That he thinks, and that which his Mind is employ'd about whilst thinking, being the Ideas, that are there, 'tis past doubt, that Men have in their Minds several Ideas, such as are those expressed by the words, Whiteness, Hardness, Sweetness, Thinking, Motion, Man, Elephant, Army, Drunkenness, and others: It is in the first place then to be inquired, How he comes by them? I know it is a received Doctrine, That Men have native Ideas, and original Characters stamped upon their Minds, in their very first Being.”

“One important object of this original spectroscopic investigation of the light of the stars and other celestial bodies, namely to discover whether the same chemical elements as those of our earth are present throughout the universe, was most satisfactorily settled in the affirmative. (1909)”

“Mr. Hillaire Belloc has pointed out that science has changed greatly, and for the worse, since it became popular. Some hundred years ago, or more, only very unusual, highly original spirits were attracted to science at all; scientific work was therefore carried out by men of exceptional intelligence. Now, scientists are turned out by mass production in our universities.”

“But although in theory physicists realize that their conclusions are ... not certainly true, this ... does not really sink into their consciousness. Nearly all the time ... they ... act as if Science were indisputably True, and what's more, as if only science were true.... Any information obtained otherwise than by the scientific method, although it may be true, the scientists will call "unscientific," using this word as a smear word, by bringing in the connotation from its original [Greek] meaning, to imply that the information is false, or at any rate slightly phony.”

“The more original a discovery, the more obvious it seems afterwards.”

“The mind, once stretched by a new idea, never returns to its original dimensions.”

“If we look round the world, there seem to be not above six distinct varieties in the human species, each of which is strongly marked, and speaks the kind seldom to have mixed with any other. But there is nothing in the shape, nothing in the faculties, that shows their coming from different originals; and the varieties of climate, of nourishment, and custom, are sufficient to produce every change.”

“No mathematician should ever allow him to forget that mathematics, more than any other art or science, is a young man's game. ... Galois died at twenty-one, Abel at twenty-seven, Ramanujan at thirty-three, Riemann at forty. There have been men who have done great work later; ... [but] I do not know of a single instance of a major mathematical advance initiated by a man past fifty. ... A mathematician may still be competent enough at sixty, but it is useless to expect him to have original ideas.”

“It is a remarkable fact that the second law of thermodynamics has played in the history of science a fundamental role far beyond its original scope. Suffice it to mention Boltzmann's work on kinetic theory, Planck's discovery of quantum theory or Einstein's theory of spontaneous emission, which were all based on the second law of thermodynamics.”

“So says the most ancient book of the Earth; thus it is written on its leaves of marble, lime, sand, slate, and clay: ... that our Earth has fashioned itself, from its chaos of substances and powers, through the animating warmth of the creative spirit, to a peculiar and original whole, by a series of preparatory revolutions, till at last the crown of its creation, the exquisite and tender creature man, was enabled to appear.”

“The books of the great scientists are gathering dust on the shelves of learned libraries. And rightly so. The scientist addresses an infinitesimal audience of fellow composers. His message is not devoid of universality but its universality is disembodied and anonymous. While the artist's communication is linked forever with its original form, that of the scientist is modified, amplified, fused with the ideas and results of others and melts into the stream of knowledge and ideas which forms our culture. The scientist has in common with the artist only this: that he can find no better retreat from the world than his work and also no stronger link with the world than his work.”

“By this we may understand, there be two sorts of knowledge, whereof the one is nothing else but sense, or knowledge original (as I have said at the beginning of the second chapter), and remembrance of the same; the other is called science or knowledge of the truth of propositions, and how things are called, and is derived from understanding.”

“A chess problem is genuine mathematics, but it is in some way "trivial" mathematics. However, ingenious and intricate, however original and surprising the moves, there is something essential lacking. Chess problems are unimportant. The best mathematics is serious as well as beautiful-"important" if you like, but the word is very ambiguous, and "serious" expresses what I mean much better.”

“And yet in a funny way our lack of success led to our breakthrough; because, since we could not get a cell line off the shelf doing what we wanted, we were forced to construct it. And the original experiment ... developed into a method for the production of hybridomas ... [which] was of more importance than our original purpose.”

“Realizing how often ingenious speculation in the complex biological world has led nowhere and how often the real advances in biology as well as in chemistry, physics and astronomy have kept within the bounds of mechanistic interpretation, we geneticists should rejoice, even with our noses on the grindstone (which means both eyes on the objectives), that we have at command an additional means of testing whatever original ideas pop into our heads.”

“They have never affirm'd any thing, concerning the cause, till the trial was past: whereas, to do it before, is a most venomous thing in the making of Sciences: for whoever has fix'd on his Cause, before he has experimented; can hardly avoid fitting his Experiment, and his Observations, to his Own Cause, which he had before imagin'd; rather than the Cause to the Truth of the Experiment itself. Referring to experiments of the Aristotelian mode, whereby a preconceived truth would be illustrated merely to convince people of the validity of the original thought.”

“My two Jamaican cousins ... were studying engineering. 'That's where the money is,' Mom advised. ... I was to be an engineering major, despite my allergy to science and math. ... Those who preceded me at CCNY include the polio vaccine discoverer, Dr. Jonas Salk ... and eight Nobel Prize winners. ... In class, I stumbled through math, fumbled through physics, and did reasonably well in, and even enjoyed, geology. All I ever looked forward to was ROTC. Autobiographical comments on his original reason for going to the City College of New York, where he shortly turned to his military career.”

“Iron and coal dominated everywhere, from grey to black: the black boots, the black stove-pipe hat, the black coach or carriage, the black iron frame of the hearth, the black cooking pots and pans and stoves. Was it a mourning? Was it protective coloration? Was it mere depression of the senses? No matter what the original color of the paleotechnic milieu might be it was soon reduced by reason of the soot and cinders that accompanied its activities, to its characteristic tones, grey, dirty-brown, black.”

“From my earliest childhood I nourished and cherished the desire to make a creditable journey in a new country, and write such a respectable account of its natural history as should give me a niche amongst the scientific explorers of the globe I inhabit, and hand my name down as a useful contributor of original matter.”

“The two revolutions, I mean the annual revolutions of the declination and of the centre of the Earth, are not completely equal; that is the return of the declination to its original value is slightly ahead of the period of the centre. Hence it necessarily follows that the equinoxes and solstices seem to anticipate their timing, not because the sphere of the fixed stars moves to the east, but rather the equatorial circle moves to the west, being at an angle to the plane of the ecliptic in proportion to the declination of the axis of the terrestrial globe.”

“Much of the geographical work of the past hundred years... has either explicitly or implicitly taken its inspiration from biology, and in particular Darwin. Many of the original Darwinians, such as Hooker, Wallace, Huxley, Bates, and Darwin himself, were actively concerned with geographical exploration, and it was largely facts of geographical distribution in a spatial setting which provided Darwin with the germ of his theory.”