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“The computer has evolved into a partner, a tool, and an environment--not just in science fiction, but in the public consciousness as well. Computers are no longer malevolent iron brains that manufacture tyrannical and oppressive answers; they are not a way to think, they are a place from which to think. The computer is an environment in which answers can be sought, created, manipulated and developed.”

“London always reminds me of a brain. It is similarly convoluted and circuitous. A lot of cities, especially American ones like New York and Chicago, are laid out in straight lines. Like the circuits on computer chips, there are a lot of right angles in cities like this. But London is a glorious mess. It evolved from a score or so of distinct villages, that merged and meshed as their boundaries enlarged. As a result, London is a labyrinth, full of turnings and twistings just like a brain.”

“Think about the way you go surfing on the Internet - you go from one thing to another. You can't really concentrate. I can't sit and read 10 pages on my computer. You'll read and then all of a sudden part of your brain is like, "What about that? ...You're not reading the whole book. You're reading fragments. Even though I think it's bad, I think it's interesting too, because that's the way my brain works.”

“Autism is a neurological disorder. It's not caused by bad parenting. It's caused by, you know, abnormal development in the brain. The emotional circuits in the brain are abnormal. And there also are differences in the white matter, which is the brain's computer cables that hook up the different brain departments.”

“All that's known is this: there is no central processor, no single computer. Nothing that simple. Millions of neurons process information simultaneously and in parallel, not linearly, but the actual chemistry and electrical properties of that integrative process are still being mapped. Even so, it seems odd that during the evolution of brain circuitry and thinking, the ability to understand itself did not get wired in. Such built-in innocence seems like a terrible oversight.”

“Computers are good at swift, accurate computation and at storing great masses of information. The brain, on the other hand, is notas efficient a number cruncher and its memory is often highly fallible; a basic inexactness is built into its design. The brain's strong point is its flexibility. It is unsurpassed at making shrewd guesses and at grasping the total meaning of information presented to it.”

“The analogy between the mind and a computer fails for many reasons. The brain is constructed by principles that assure diversity and degeneracy. Unlike a computer, it has no replicative memory. It is historical and value driven. It forms categories by internal criteria and by constraints acting at many scales, not by means of a syntactically constructed program. The world with which the brain interacts is not unequivocally made up of classical categories.”

“I've noticed that nowadays I'm doing a lot of stuff on the phone and on the computer, which I usually wouldn't do earlier. And I can feel my brain being rewired: I'm getting anxious, I'm getting more manic. Now, I'm an extreme case because I'm old and I'm overdoing it. But still, it's really interesting that I can actually feel a change in my neurochemistry from this interaction with the technology.”

“"Nothing is ever lost" means that what we are now goes all the way back through natural history. We are biological organisms and not simply computerized brains. By focusing totally on the present, thinking only about science and computers, and forgetting four billion years of life on this planet, we are losing perspective on who and what we are.”

“John Coltrane is still probably one of the greatest musicians of this century. His tone truly puts demons on a leash. His gift is directly from the mind of God and is very powerful. ..... The first time I heard a Love Supreme, it was really an assault. It could've been from mars as far as i was concerned, or another galaxy. I remember the album cover and the name, but the music didn't fit into the patterns of my brain at that point. It was like someone trying to tell a monkey about spirituality or computers, you know, it just didn't compute.”

“The first proponent of cortical memory networks on a major scale was neither a neuroscientist nor a computer scientist but .. a Viennes economist: Friedrich von Hayek (1899-1992). A man of exceptionally broad knowledge and profound insight into the operation of complex systems, Hayek applied such insight with remarkable success to economics (Nobel Prize, 1974), sociology, political science, jurisprudence, evolutionary theory, psychology, and brain science (Hayek, 1952).”

“Essentially, there's a universe inside your brain. The number of connections possible inside your brain is limitless. And as people have learned to have more managerial and direct creative access to their brains, they have also developed matrices or networks of people that communicate electronically. There are direct brain/computer link-ups. You can just jack yourself in and pilot your brain around in cyberspace-electronic space.”

“When we look at these historical women and what they've gone through, it's shocking to recognize some of our own experiences in theirs. When you look at someone like Ada Lovelace who is the first computer programmer, during her lifetime doctors said that was really sick because she was trying to use a masculine kind of brain that she didn't have. Today, her legacy of being the first programmer is stil disputed.”

“I think the definition will change as we learn more, but my working definition of solving the brain is: one, we can model, maybe in a computer, the processes that generate things like thoughts and feelings, and two, we can understand how to cure brain disorders, like Alzheimer's and epilepsy. Those are my two driving goals. One is more human-condition oriented, and one more clinical.”

“I've been recognized every now and then. It's always in computer stores. It's something like brain associations, because I'll be in the grocery store and nobody will recognize me. Even in my glasses, looking exactly like my picture, nobody will recognize me. But I could be totally clean-shaven, hat on, looking nothing like myself in a computer store, and they're like, "Snowden?!"”

“As Walt Whitman correctly surmised, we are large and we harbor multitudes within us. And those multitudes are locked in chronic battle. There is an ongoing conversation among the different factions in your brain, each competing to control the single output channel of your behavior. As a result, you can accomplish the strange feats of arguing with yourself, cursing at yourself, and cajoling yourself to do something - feats that modern computers simply do not do.”

“Computers get better, faster than anything else ever. A child's PlayStation today is more powerful than a military supercomputer from 1996. But our brains are wired for a linear world. As a result, exponential trends take us by surprise. I used to teach my students that there are some things, you know, computers just aren't good at like driving a car through traffic.”