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“Science, unguided by a higher abstract principle, freely hands over its secrets to a vastly developed and commercially inspired technology, and the latter, even less restrained by a supreme culture saving principle, with the means of science creates all the instruments of power demanded from it by the organization of Might.”

“THE COMPUTER IS JUST AN INSTRUMENT for doing faster what we already know how to do slower. All pretensions to computer intelligence and paradise-tomorrow promises should be toned down before the public turns away in disgust. And if that should happen, our civilization might not survive.”

“A bird is an instrument working according to mathematical law, which instrument it is within the capacity of man to reproduce with all its movements, but not with a corresponding degree of strength, though it is deficient only in the power of maintaining equilibrium. We may therefore say that such an instrument constructed by man is lacking in nothing except the life of the bird, and this life must needs be supplied from that of man.”

“It were indeed to be wish'd that our art had been less ingenious, in contriving means destructive to mankind; we mean those instruments of war, which were unknown to the ancients, and have made such havoc among the moderns. But as men have always been bent on seeking each other's destruction by continual wars; and as force, when brought against us, can only be repelled by force; the chief support of war, must, after money, be now sought in chemistry.”

“I would by all means have men beware, lest Æsop's pretty fable of the fly that sate [sic] on the pole of a chariot at the Olympic races and said, 'What a dust do I raise,' be verified in them. For so it is that some small observation, and that disturbed sometimes by the instrument, sometimes by the eye, sometimes by the calculation, and which may be owing to some real change in the heaven, raises new heavens and new spheres and circles.”

“Even in Europe a change has sensibly taken place in the mind of man. Science has liberated the ideas of those who read and reflect, and the American example has kindled feelings of right in the people. An insurrection has consequently begun of science talents and courage against rank and birth, which have fallen into contempt. It has failed in its first effort, because the mobs of the cities, the instrument used for its accomplishment, debased by ignorance, poverty and vice, could not be restrained to rational action. But the world will soon recover from the panic of this first catastrophe.”

“Scientific research was much like prospecting: you went out and you hunted, armed with your maps and instruments, but in the ened your preparations did not matter, or even your intuition. You needed your luck, and whatever benefits accrued to the diligent, through sheer, grinding hard work.”

“Knowledge is like a knife. In the hands of a well-balanced adult it is an instrument for good of inestimable value; but in the hands of a child, an idiot, a criminal, a drunkard or an insane man, it may cause havoc, misery, suffering and crime. Science and religion have this in common, that their noble aims, their power for good, have often, with wrong men, deteriorated into a boomerang to the human race.”

“The chemists work with inaccurate and poor measuring services, but they employ very good materials. The physicists, on the other hand, use excellent methods and accurate instruments, but they apply these to very inferior materials. The physical chemists combine both these characteristics in that they apply imprecise methods to impure materials.”

“But science is the great instrument of social change, all the greater because its object is not change but knowledge, and its silent appropriation of this dominant function, amid the din of political and religious strife, is the most vital of all the revolutions which have marked the development of modern civilisation.”

“I have accumulated a wealth of knowledge in innumerable spheres and enjoyed it as an always ready instrument for exercising the mind and penetrating further and further. Best of all, mine has been a life of loving and being loved. What a tragedy that all this will disappear with the used-up body!”

“While the vaccine discovery was progressive, the joy I felt at the prospect before me of being the instrument destined to take away from the world one of its greatest calamities [smallpox], blended with the fond hope of enjoying independence and domestic peace and happiness, was often so excessive that, in pursuing my favourite subject among the meadows, I have sometimes found myself in a kind of reverie.”

“The historian of science may be tempted to claim that when paradigms change, the world itself changes with them. Led by a new paradigm, scientists adopt new instruments and look in new places. even more important, during revolutions, scientists see new and different things when looking with familiar instruments in places they have looked before. It is rather as if the professional community had been suddenly transported to another planet where familiar objects are seen in a different light and are joined by unfamiliar ones as well.”

“The resolution of revolutions is selection by conflict within the scientific community of the fittest way to practice future science. The net result of a sequence of such revolutionary selections, separated by periods of normal research, is the wonderfully adapted set of instruments we call modern scientific knowledge.”

“For those [observations] that I made in Leipzig in my youth and up to my 21st year, I usually call childish and of doubtful value. Those that I took later until my 28th year [i.e., until 1574] I call juvenile and fairly serviceable. The third group, however, which I made at Uraniborg during approximately the last 21 years with the greatest care and with very accurate instruments at a more mature age, until I was fifty years of age, those I call the observations of my manhood, completely valid and absolutely certain, and this is my opinion of them.”

“The day when the scientist, no matter how devoted, may make significant progress alone and without material help is past. This fact is most self-evident in our work. Instead of an attic with a few test tubes, bits of wire and odds and ends, the attack on the atomic nucleus has required the development and construction of great instruments on an engineering scale.”

“The science and technology which have advanced man safely into space have brought about startling medical advances for man on earth. Out of space research have come new knowledge, techniques and instruments which have enabled some bedridden invalids to walk, the totally deaf to hear, the voiceless to talk, and, in the foreseeable future, may even make it possible for the blind to "see."”

“From the point of view of the pure morphologist the recapitulation theory is an instrument of research enabling him to reconstruct probable lines of descent; from the standpoint of the student of development and heredity the fact of recapitulation is a difficult problem whose solution would perhaps give the key to a true understanding of the real nature of heredity.”

“[The infinitely small] neither have nor can have theory; it is a dangerous instrument in the hands of beginners [ ... ] anticipating, for my part, the judgement of posterity, I would dare predict that this method will be accused one day, and rightly, of having retarded the progress of the mathematical sciences.”

“There is no instrument for measuring the pressure of the Ether, which is probably millions of times greater: it is altogether too uniform for direct apprehension. A deep-sea fish has probably no means of apprehending the existence of water, it is too uniformly immersed in it: and that is our condition in regard to the Ether.”

“I am not yet so lost in lexicography, as to forget that words are the daughters of the earth, and that things are the sons of heaven. Language is only the instrument of science, and words are but the signs of ideas: I wish, however, that the instrument might be less apt to decay, and that signs might be permanent, like the things which they denote.”