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“I have been diagnosed with Amyotrophic Lateral Sclerosis (ALS). It's a terminal disease with an average lifespan of two to five years post-diagnosis, and scientists don't know what causes it. ALS prevents your brain from talking to your muscles. As a result, muscles die. As a result, every 90 minutes people die. I am a person.”

“An essential aspect of creativity is not being afraid to fail. Scientists made a great invention by calling their activities hypotheses and experiments. They made it permissible to fail repeatedly until in the end they got the results they wanted. In politics or government, if you made a hypothesis and it didn't work out, you had your head cut off.”

“To play chess on a truly high level requires a constant stream of exact, informed decisions, made in real time and under pressure from your opponent. What's more, it requires a synthesis of some very different virtues, all of which are necessary to good decisions: calculatioñ, creativity and a desire for results. If you ask a Grandmaster, an artist and a computer scientist what makes a good chess player, you'll get a glimpse of these different strengths in action.”

“When reputable scientists correct flaws in an experiment that produced fantastic results, then fail to get those results when they repeat the test with flaws corrected, they withdraw their original claims. They do not defend them by arguing irrelevantly that the failed replication was successful in some other way, or by making intemperate attacks on whomever dares to criticize their competence.”

“Scientists are used to debating with one another about the finer points of new research. But increasingly, they find themselves battling their televisions and computer screens, which transmit ever-more-heated rhetoric from politicians, pundits, and other public figures who misinterpret, misrepresent, and malign scientific results.”

“The NSF study projected a shortfall of 675,000 scientists and engineers without considering the future demand for such individuals in the marketplace. It simply observed a decline in the number of 22-year-olds and projected that this demographic trend would result in a huge shortfall. This could be termed the supply-side theory of labor market analysis. But making labor market projections without considering the demand side of the equation doesn't pass the laugh test with experts in the field.”

“Even the great scientists have reported that their creative break-throughs came at a time of mental quietude. The surprising result of a nationwide inquiry among America's most eminent mathematicians, including Einstein, to find out their working methods, was that thinking 'plays only a subordinate part in the brief, decisive phase of the creative act itself'.”

“Scientists used to do an experiment whereby a dog's repeated reward for performing a task was unaccountably replaced by punishment. The dog, knowing it would be penalized for doing well or doing badly, would become melancholic and inactive. This and other unforeseeable results were funded by taxing up to sixty percent of people's earnings. People became strangely melancholic and inactive”

“A … difference between most system-building in the social sciences and systems of thought and classification of the natural sciences is to be seen in their evolution. In the natural sciences both theories and descriptive systems grow by adaptation to the increasing knowledge and experience of the scientists. In the social sciences, systems often issue fully formed from the mind of one man. Then they may be much discussed if they attract attention, but progressive adaptive modification as a result of the concerted efforts of great numbers of men is rare.”

“When a scientist doesn't know the answer to a problem, he is ignorant. When he has a hunch as to what the result is, he is uncertain. And when he is pretty darn sure of what the result is going to be, he is still in some doubt. We have found it of paramount importance that in order to progress we must recognize our ignorance and leave room for doubt. Scientific knowledge is a body of statements of varying degrees of certainty - some most unsure, some nearly sure, but none absolutely certain.”

“The material which a scientist actually has at his disposal, his laws, his experimental results, his mathematical techniques, his epistemological prejudices, his attitude towards the absurd consequences of the theories which he accepts, is indeterminate in many ways, ambiguous, and never fully separated from the historical background . This material is always contaminated by principles which he does not know and which, if known, would be extremely hard to test.”

“These are people from everywhere, from Lawrence Livermore and JPL and Sandia National Labs, the FBI, all over the place, real scientists who see what we're doing, and they consistently thank us. "I agree your results aren't always right," they'll say, "but your methods are clearly showing that science is a re-creative process, and it's an interesting process because it's messy, and no other shows show that."”

“Science has long been in the value business. Despite a widespread belief to the contrary, scientific validity is not the result of scientists abstaining from making value judgments; rather, scientific validity is the result of scientists making their best efforts to value principles of reasoning that link their beliefs to reality, through reliable chains of evidence and argument.”