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“I think the way we think about cancer, the way we treat cancer, has dramatically changed in the last century. There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients or providing patients with psychic solace or pain relief.”

“When I was eight years old, I wrote a paragraph-long short story about a goat on my mother's hundred-pound, black-and-white-screen laptop. The story came about largely because I liked the way the word 'goat' looked on the page, but I decided then and there that I wanted to be a writer. That desire never changed.”

“For me, the moment the mic is on and it's rolling, it's impossible to vocally relax for some reason. But one day, I'm going to be able to sing the way I sang when I was a little kid, completely open and free. That's, I think, the one thing that's changed: Growing older, I'm not ashamed to hear my voice.”

“The one thing I miss is hitchhiking. Now there's no more of that. When's the last time you saw a hitchhiker? It's not that I consider it a great sport, but it was my way of seeing the country. The open road, especially in the western United States, is still very pristine, but everything else around it has changed.”

“Customers don't know what they want. There's plenty of good psychology research that shows that people are not able to accurately predict how they would behave in the future. So asking them, 'Would you buy my product if it had these three features?' or 'How would you react if we changed our product this way?' is a waste of time. They don't know.”

“How do they find out with the experiments?''...one way they can find out a whole lot is to make an animal ill and then try different ways to make it better until they find one that works.''But isn't that unkind to the animal?''Well, I suppose it is...but I mean, there isn't a dad anywhere who would hesitate, is there, if he knew it was going to make [his child] better? It's changed the whole world during the last hundred years, and that's no exaggeration.”

“It all changed when I realized I'm not the only one on the planet who's scared. Everyone else is, too. I started asking people, Are you scared, too? You bet your sweet life I am. Aha, so that's the way it is for you, too. We were all in the same boat. That's probably what is so effective at our workshops. When I ask, Who else feels like this? the whole room of hands goes up. People realize they are not the only one who feels that way.”

“The sport has changed so much since 2004, it's incredible. If you look even at me, the way I'm fencing now compared to 2004, it's a completely different sport. They've changed so many things just with what [the referees] are calling, they've changed the timing of the [scoring] lights. You always have to be evolving as a fencer. The Olympics is interesting because it's such a small field compared to what we're used to. This world championships, I think we had a hundred and something [athletes]. The Olympics is going to be less than 32.”

“It is a curious situation that the sea, from which life first arose, should now be threatened by the activities of one form of that life. But the sea, though changed in a sinister way, will continue to exist: the threat is rather to life itself.”

“Living on the street as a kid changed the way I looked at everything. It was a different time and while it had its dangers, it was nothing like it would be today. It was the Summer of Love and there was a real sense of community among us. We were hippies who looked out for each other instead of trying to rip each other off. We only had to watch out for the police who liked to roust us just on general principles, and the kids who came in from the suburbs to do a little hippie-bashing.”

“Continuously thou wilt look at human things as smoke and nothing at all; especially if thou reflectest at the same time, that what has once changed will never exist again in the infinite duration of time. But thou, in what a brief space of time is thy existence? And why art thou not content to pass through this short time in an orderly way?”

“Those who first invented and then named the constellations were storytellers. Tracing an imaginary line between a cluster of stars gave them an image and an identity. The stars threaded on that line were like events threaded on a narrative. Imagining the constellations did not of course change the stars, nor did it change the black emptiness that surrounds them. What it changed was the way people read the night sky.”

“London has changed enormously and so have the English in the past decade. They're more like Americans and more like Europeans, too. They're always eating out, and when they're at home they don't cook the way they did ten years ago. They're all sitting around in cafés, like the Continentals, drinking coffee and chattering and watching the world go by.”

“In Bergman's world I represented a sort of intellectual, skeptical, ironic person, rather cold and frustrated. When I went abroad and made films in Italy and other places, I was used in different ways. I was rather often cast as crazy people, maniacs. It was very good for me and it was fun because it is nice to play crazy people if you are not in reality. And I think perhaps that changed how Ingmar saw me. Suddenly I was on the more magical side of his world, playing the people with fantasies, variety, the artists.”

“You asked if I thought my fiction had changed anything in the culture and the answer is no. Sure, there's been some scandal, but people are scandalized all the time; it's a way of life for them. It doesn't mean a thing. If you ask if I want my fiction to change anything in the culture, the answer is still no. What I want is to possess my readers while they are reading my book — if I can, to possess them in ways that other writers don't. Then let them return, just as they were, to a world where everybody else is working to change, persuade, tempt, and control them.”

“He who remembers the evils he has undergone, and those that have threatened him, and the slight causes that have changed him from one state to another, prepares himself in that way for future changes and for recognizing his condition. The life of Caesar has no more to show us than our own; an emperor's or an ordinary man's, it is still a life subject to all human accidents.”

“I am a technophile, so there is no such thing as a first draft. The first draft plunges on, and about a quarter of the way through it I realise I'm doing things wrong, so I start rewriting it. What you call the first draft becomes rather like a caterpillar; it is progressing fairly slowly, but there is movement up and down its whole length, the whole story is being changed. I call this draft zero, telling myself how the story is supposed to go.”

“I went down to London with the idea that I was going to do vocals over this crazy, crazy trip-hop digital beat. Within two or three months, I heard Hunky Dory by David Bowie and that changed me in one way, and I realized what I actually wanted was to have an E Street Band - individuals, not session musicians.”