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“I think the way we think about cancer, the way we treat cancer, has dramatically changed in the last century. There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients or providing patients with psychic solace or pain relief.”

“Today as in the time of Pliny and Columella, the hyacinth flourishes in Wales, the periwinkle in Illyria, the daisy on the ruins of Numantia; while around them cities have changed their masters and their names, collided and smashed, disappeared into nothingness, their peaceful generations have crossed down the ages as fresh and smiling as on the days of battle.”

“Living on the street as a kid changed the way I looked at everything. It was a different time and while it had its dangers, it was nothing like it would be today. It was the Summer of Love and there was a real sense of community among us. We were hippies who looked out for each other instead of trying to rip each other off. We only had to watch out for the police who liked to roust us just on general principles, and the kids who came in from the suburbs to do a little hippie-bashing.”

“Space has not changed but technology has, in many cases, improved dramatically. A good example is digital technology where today's cell phones are far more powerful than the computers on the Apollo Command Module and Lunar Module that we used to navigate to the moon and operate all the spacecraft control systems.”

“My life has changed because somebody fed my family on Thanksgiving when I was eleven years old. It wasn't the food that changed me, it was the fact that a stranger cared. That's what changed my life. That made me the person I am today and have been for the last 37 years. All that came out of that, that simple act of getting a result.”

“The sea erupted. Often the sea and land changed places. The immobility of contours of continents and seas, a dogma in geology, has no basis in fact. And immediately there is the problem of the climate. There were ancient climates that were very different from what they are today. If those corals grew where they were found, certainly the Earth was not travelling with the same elements of rotation and revolution which means not in the same orbit, not with the axis directed in the same position as it is today. If you don't believe it, try to conservate corals on the North Pole.”

“To be sure, [NASCAR] stars were initially ex-bootleggers for the most part drawn from that talent pool in the Carolinas hills: "good ol' boys" as they referred to themselves. That's exactly how they would be described in the press that slowly became enamored with their raucous life style. That has all changed, with the drivers of today polished and clean-cut athletes who are expected to behave like commercial puppets in public.”

“We are free today substantially, but the day will come when our Republic will be an impossibility. It will be an impossibility because wealth will be concentrated in the hands of a few. A Republic cannot stand upon bayonets, and when the day comes when the wealth of the nation will be in the hands of a few, then we must rely upon the wisdom of the best elements in the country to readjust the laws of the nations to the changed conditions.”

“The full implications of feminism will evolve over time, as we organize, experiment, think, analyze, and revise our ideas and strategies in light of our experiences. No theory emerges in full detail overnight; the dominant theories of our day have expanded and changed over many decades. That it will take time should not discourage us. That we might fail to pursue our ideas - given the enormous need for them in society today - is unconscionable.”

“It seems like only yesterday that savers were dorks. They kept piggy banks. They drove last year's cars. They fished in their change purses for nickels while the superstars flashed credit cards. Today, values have changed. The new object of veneration is not money on the hoof but money in the bank - and the dorks all have it.”

“At times it may seem as though you and your past are one. Sometimes we fail to differentiate between what has happened to us and who we are today. If you have a hard time getting beyond that damaging mind-set let me encourage you right now. You are not your past Although you are changed and shaped by past experiences who you were yesterday does not control the person you have the potential to become tomorrow.”

“Films are made the same today, as they've ever been made, in certain respects. The scriptwriting, the pre-production, the storyboarding, and the designing are all the same. The technique of animation has changed, in the sense that rather than drawing it by hand, we use a computer as a tool. The computer has become a pencil to draw or paint the images that we see in a film.”

“I learned to live many years ago. Something really, really bad happened to me, something that changed my life in ways that, if I had my druthers, it would never have been changed at all. What I learned from it is that today seems to be the hardest lesson of all. I learned to love the journey, not the destination. I learned that it is not a dress rehearsal, and that today is the only guarantee you get. I learned to look at all the good in the world and to try to give some of it back because I believed in it completely and utterly.”

“I don't know how much things have changed. You still need to be able to run the ball, pick up blitzes and catch the ball out of the backfield. Perhaps you need a running back to do a little bit more or be more versatile today but that is a good thing. People say we get hurt and don't last as long, but it's still an important position and you need everyone in the backfield to be able to contribute.”

“John Hughes made a certain type of high school movie, and then it stayed static for 30 years. The only thing that changed was that maybe it was found footage or maybe it's a little snarkier, but the actual language that kids live in today, like with texting, motion graphics, the internet and that whole hashtag culture doesn't exist in movies today. It's left on the floor.”

“While the machinery of law enforcement and indeed the nature of crime itself have changed dramatically since the Fourth Amendment became part of the Nation's fundamental law in 1791, what the Framers understood then remains true today - that the task of combating crime and convicting the guilty will in every era seem of such critical and pressing concern that we may be lured by the temptations of expediency into forsaking our commitment to protecting individual liberty and privacy.”

“Nothing has really changed. We had bootleg albums in the '60s and today we have Internet file sharing. They just found a better way to do it -- get music for free. What's great about today is an artist has an opportunity to go direct to their audience without dealing with a middleman. People can go directly to the web for CDs, DVDs and downloads. I think that's the best thing that's happened, that people's music is being flashed around the world.”

“Today, the growers are like a punch-drunk old boxer who doesn't know he's past his prime. The times are changing. The political and social environment has changed. The chickens are coming home to roost - and the time to account for past sins is approaching.”

“I remember working with Jackie Chan on Shanghai Noon [2000], and when we were working on the script, I thought that my character thought about being an outlaw the way a kid today would think about being a rock star, as a way to impress girls. So it was just kind of a funny idea, but once we had that idea, it changed the character and made it something that was funnier to me to play.”