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“I think the way we think about cancer, the way we treat cancer, has dramatically changed in the last century. There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients or providing patients with psychic solace or pain relief.”

“The one thing I miss is hitchhiking. Now there's no more of that. When's the last time you saw a hitchhiker? It's not that I consider it a great sport, but it was my way of seeing the country. The open road, especially in the western United States, is still very pristine, but everything else around it has changed.”

“How do they find out with the experiments?''...one way they can find out a whole lot is to make an animal ill and then try different ways to make it better until they find one that works.''But isn't that unkind to the animal?''Well, I suppose it is...but I mean, there isn't a dad anywhere who would hesitate, is there, if he knew it was going to make [his child] better? It's changed the whole world during the last hundred years, and that's no exaggeration.”

“America is a large country and its people have so far not shown much interest in great international problems, among which the problem of disarmament occupies first place today. This must be changed, if only in America's own interest. The last war has shown that there are no longer any barriers between the continents and that the destinies of all countries are closely interwoven. The people of this country must realize that they have a great responsibility in the sphere of international politics. The part of passive spectator is unworthy of this country and is bound in the end to lead to disaster all round.”

“My life has changed because somebody fed my family on Thanksgiving when I was eleven years old. It wasn't the food that changed me, it was the fact that a stranger cared. That's what changed my life. That made me the person I am today and have been for the last 37 years. All that came out of that, that simple act of getting a result.”

“The very word "change" has changed. When I was young--and not just because I was young--we looked forward with confident impatience to change. Planned, controlled, beneficent change would continue to clear slums, sweep up the remains of empire, raise living and educational standards, tidy away--firmly but kindly--the last aboriginals who still raved about martial glory or the pride of wealth. Now, as it seems to me, change is set almost exclusively in the minor key, change seen overwhelmingly as loss.”

“We have worked very hard to accommodate the requests from the Mayor and the Council that changed the terms of the agreement that brought the Montreal Expos to Washington. Because we believe in the future of Baseball in the nation's capital, we have signed a lease that honors the 2004 agreement, while conforming to the emergency legislation that the Council passed last month.”

“I myself am not comfortable with the notion of secularists congregating in groups, except perhaps for defensive purposes: the last thing a secularist should wish to do is to act like a religion, with its rigid hierarchies, its suppression of divergent opinion, and, above all, its ruthless attempts (now mercifully inhibited by laws) to outlaw "heresy" by brute force. Opinions must be changed, one at a time if necessary, but if there are those who wish to persist in religious belief, they should certainly be allowed to do so.”

“I don't think I've changed very much. I think I'm the same kid that I was when I got here. When I came here all I wanted to do was win games. I wanted to play baseball for LSU and be the ultimate team player. That's all I want to do. If we don't end up being the last team to win the game at the end of the year then I won't be happy. That's all I'm worried about this year.”

“It seems like only yesterday that savers were dorks. They kept piggy banks. They drove last year's cars. They fished in their change purses for nickels while the superstars flashed credit cards. Today, values have changed. The new object of veneration is not money on the hoof but money in the bank - and the dorks all have it.”

“You loved people and you came to depend on their being there. but people died or changed or went away and it hurt too much. The only way to avoid that poin was not to love anyone, and not to let anyone get too close or too important. The secret of not being hurt like this again, I decided, was never depending on anyone, never needing, never loving.It is the last dream of children, to be forever untouched.”

“Oh, how quickly things changed! Why didn't happiness last for ever? For ever wasn't a bit too long.”

“In 1982 I bought the newly released Makina Plaubel 55mm fixed-lens camera. With this shift from 35mm to 6 x 7, I also changed from black and white to color. Later that year, I started my project on New Brighton called The Last Resort. However, the first project I shot in colour was composed of urban scenes from Liverpool. This image was on the second roll of film. It's the first good photo I made in this new chapter of my work.”

“The way we eat has changed more in the last 50 years than in the previous 10,000…. Now our food is coming from enormous assembly lines where the animals and the workers are being abused, and the food has become much more dangerous in ways that are deliberately hidden from us. This isn’t just about what we’re eating. It’s about what we’re allowed to say. What we’re allowed to know.”

“Think of our DNA. In the last million years, our DNA hasn't changed at all. It's really much the same as it was in the jungle, a million, two millions years ago. But in the last 200 years, our destructive capacities have increased many, many millions of times over. Why don't we see intelligent signals from outer space? Because in all likelihood, once the civilization reaches the point our civilization has reached, it destroys itself.”

“The "female culture" has shifted more rapidly than the "male culture"; the image of the go-get 'em woman has yet to be fully matched by the image of the let's take-care-of-the-kids- together man. More important, over the last thirty years, men's underlying feelings about taking responsibility at home have changed much less than women's feelings have changed about forging some kind of identity at work.”

“Communication has changed so rapidly in the last 20 years, it's almost impossible to predict what might occur even in the next decade. E-mail, which now sends data hurtling across vast distances at the speed of light, has replaced primitive forms of communication such as smoke signals, which sent data hurtling across vast distances at the speed of light.”

“I believe order is better than chaos, creation better than destruction. I prefer gentleness to violence, forgiveness to vendetta. On the whole I think that knowledge is preferable to ignorance, and I am sure that human sympathy is more valuable than ideology. I believe that in spite of the recent triumphs of science, men haven't changed much in the last two thousand years; and in consequence we must try to learn from history.”

“"The Diagnosis" had ten drafts of very significant changing, where I went through the whole book, wholesale and changed everything. Then the last year or so it was making small changes. I would do something and let it sit for three months... just brood about and decide I needed to slightly change something here or there. Or one character wasn't quite right. But I think everybody goes through this.”

“You know, whenever you're shooting a film there's different obstacles and challenges, whether it be from the makeup artist getting fired that you liked or whatever - the one that did the makeup the way you wanted. There's always stuff that changed, like the DP leaving the set, and there's a new guy in there, and the way he does lighting isn't the same as the last guy.”

“I don't know how much things have changed. You still need to be able to run the ball, pick up blitzes and catch the ball out of the backfield. Perhaps you need a running back to do a little bit more or be more versatile today but that is a good thing. People say we get hurt and don't last as long, but it's still an important position and you need everyone in the backfield to be able to contribute.”

“What happened with Final Destination was that the movie was in post-production for a long time and I think they changed a lot of the deaths, so a lot of those things were last-minute additions. Everything we shot is in the movie and it's all been designed. We didn't change anything. It's been a year of making those things happen, exactly as we had pictured them.”

“I think the way the country has changed in part because of the presidency of Barack Obama, I think in part because of what we`ve - the violence that we have seen on our cell phones and our TV sets over the last couple of years. I think Black Lives Matter has helped to force these issues. Women like Sabrina Fulton. We`re having a different conversation in this country right now about race and what it means to really understand your experience is and my experience is.”

“There are other concerns in this state [of Mecklenburg-Western Pomerania], which is one of the prettiest. It's also one of the poorest, where people here are making less than the national average. Unemployment is higher than the national average, and a lot of the young people, especially, have left because there just aren't jobs and that sort of thing. So you have that going on, the feeling that that hasn't really changed in years or at least with their help - with the last state government.”

“Humans used to desire love, money, food, shelter, safety, peace and freedom more than anything else. The last 30 years have changed us. Now people want to have a good job, and they want their children to have a good job. This changes everything for world leaders. Everything they do - from waging war to building societies - will need to be carried out within the new context of the need for a good job.”