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“Think of it: the lowest common denominator in being digital is not your operating system, modem, or model of computer. It's a tiny piece of plastic, designed decades ago by Bell Labs' Charles Krumreich, Edwin Hardesty, and company, who thought they were making an inconspicuous plug for a few telephone handsets. Not in their wildest dreams was Registered Jack 11 - a modular connector more commonly known as the RJ-11 - meant to be plugged and unplugged so many times, by so many people, for so many reasons, all over the world.”

“To many of us now, computers, silicon chips, data processing, cybernetics, and all the other innovations of the dawning high technology age are as mystifying as the workings of the combustion engine must have been when that first Model T rattled down Main Street, U.S.A. But as surely as America's pioneer spirit made us the industrial giant of the 20th century, the same pioneer spirit today is opening up on another vast front of opportunity, the frontier of high technology.”

“Holland's and Kauffman's work, together with Dawkins' simulations of evolution and Varela's models of autopoietic systems, provide essential inspiration for the new discipline of artificial life, This approach, initiated by Chris Langton (1989, 1992), tries to develop technological systems (computer programs and autonomous robots) that exhibit lifelike properties, such as reproduction, sexuality, swarming, and co-evolution.”

“What's missing from the online experience is community. Married couples are still going to need something to do on Tuesday nights, right? And it's not going to be individually retiring to their offices to watch on their computers. It's: "We just put the meat loaf dishes away, let's go watch television." It's going to happen. We shouldn't be so led around by other models.”

“The idea that hardware on networks should just be caches for movable process descriptions and the processes themselves goes back quite a ways. There's a real sense in which MS and Apple never understood networking or operating systems (or what objects really are), and when they decided to beef up their OSs, they went to (different) very old bad mainframe models of OS design to try to adapt to personal computers.”

“India just went 3 years with no cases [of polio]. Pakistan is our toughest location right now because some parts of the Taliban have not allowed vaccinators to come in and have even attacked vaccinators. We are hopeful this will get resolved since no one wants their kid to be paralyzed. I spend a lot of time making sure the polio campaign is doing the best it can. We have great computer models that help guide our activities.”

“The Environmental Protection Agency's (EPA) own computer model easily shows that President Obama's proposed regulations would reduce global warming by around 0.02 of a degree Celsius by the year 2100. Actually, the true number is probably even smaller because that calculation assumes a future rate of warming - there hasn't been any for 17 years now - quite a bit higher than it is likely to be.”

“I met designers that are in the business for ten years in the movies, and their biggest complaint is things don't look anything like they were designed. Look at my drawing! But nobody ever sees the drawing, that's the thing. So I knew right from the beginning that I would design everything in 3D on my computer, and those models literally went to the machines. So every little radius on most of the vehicles you see there, I built with my mouse and keyboard.”

“As the popular trust in science fades - and many sociologists say that's happening today - people will develop a distrust of purely "scientific" psychology. Researchers in the universities haven't picked up on this; they're more interested in genetics and computer models of thinking than ever. But, in general, there is a huge distrust of the scientific establishment now.”

“I think the definition will change as we learn more, but my working definition of solving the brain is: one, we can model, maybe in a computer, the processes that generate things like thoughts and feelings, and two, we can understand how to cure brain disorders, like Alzheimer's and epilepsy. Those are my two driving goals. One is more human-condition oriented, and one more clinical.”

“When Colin Powell showed up as Secretary of State in 2001, most State Department employees still didn't even have computers on their desks. When I got there they were not mostly permitted to have handheld devices. I mean, so you're thinking how do we operate in this new environment dominated by technology, globalizing forces? We have to change, and I can't expect people to change if I don't try to model it and lead it.”

“If somebody is working on a new medicine, computer science helps us model those things. We have a whole group here in Seattle called the Institute for Disease Modelling that is a mix of computer science and math-type people, and the progress we're making in polio or plans for malaria or really driven by their deep insights.”

“In the future, every human will have a digital model of their body stored in computers. When someone needs a new shoe or a new bra or a new prosthesis or a new brace, s/he'll just fabricate it from the digital model themselves and then the device or article will be delivered to the home without even having to go to a retail store. The shoe, the bra, the brace, it'll be the person's apparel, the person's device, no one else's. It'll be exquisitely comfortable and functional. So this whole notion today where we have sizing to fit across humans is just utterly absurd.”

“The only basis for even talking about global warming is the predictions spewed out by computer models. The only quote/unquote "evidence" of global warming is what models are predicting the climate and the weather will be in the next 50 to 100 years. Now, what those models spit out is only as good as the data that's put in, and it's an absolute joke. In terms of science, it's a total joke. There is no warming, global or otherwise!”

“Because we do not understand the brain very well we are constantly tempted to use the latest technology as a model for trying to understand it. In my childhood we were always assured that the brain was a telephone switchboard...Sherrington, the great British neuroscientist, thought the brain worked like a telegraph system. Freud often compared the brain to hydraulic and electromagnetic systems. Leibniz compared it to a mill...At present, obviously, the metaphor is the digital computer.”