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“If all other risk factors are normal, and you exercise moderately, your risk of having high CRP is one in 2000, .. A person who is a little overweight, with blood fats and cholesterol a little elevated, maybe with a little bit of high blood pressure -- we didn't used to think that having several of these little risk factors were a big deal. But it is. These little risk factors add up in a way that is worse for you than one big risk factor.”

“Automobile in America,Chromium steel in America,Wire-spoke wheel in America,Very big deal in America!Immigrant goes to America,Many hellos in America,Nobody knows in America,Puerto Rico's in America!I like the shores of America!Comfort is yours in America!Knobs on the doors in America!Wall-to-wall floors in America!”

“What matters is performances, regardless of what the name is, whether it's The Rock - which is my nickname and people call me that all the time - it's no big deal. So, whether it's The Rock or Dwayne Johnson, in terms of being recognised I just think that the goal is to be recognised as a good actor. I don't put much thought or weight into the name, or the name change, or what it is, or what does it mean? It's just a nickname.”

“Adolescence hits boys harder than it does girls. Girls bleed a little and their breasts pop out, big deal, but adolescence lands on a guy with both feet. . . . Your body is engulfed by chemicals of rage and despair, you pound, you shriek, you batter your head against the trees. You come away wounded, feeling that life is unknowable, can never be understood, only endured and sometimes cheated.”

“The whole first movie [Twilight] was pretty fun. I had never really done a movie like it, when there's such a big cast of people that are around about the same age. Everyone didn't really know what was going to happen with the movie, but there was a good energy. There was something which people were fighting for, in a way. They wanted it to be something special. None of us were really known then, as well. It felt like a big deal, at the time.”

“I have been very lucky because I have had the opportunity to see what it's like to have little or no money and what it's like to have a lot of it. I'm lucky because people make such a big deal of it and, if I didn't experience both, I wouldn't be able to know how important it really is for me. I can't comment on what having a lot of money means to others, but I do know that for me, having a lot more money isn't a lot better than having enough to cover the basics.”

“It's a big deal about whether or not gays can march in the St. Patrick's Day Parade and I have to say that on some level I kind of see their point. Because when you think about it, it is a real macho heterosexual event. Bunch of guys in short skirts on a cart made of rose pedals sharing a bag pipe. That's not for sissies.”

“At the end of the day, I think there is an important moment happening in our society right, and I have to do the right thing. At the end of the day, I don't label myself one way or another. I come from a place where I find it hard to identify with a label. I've dated men in the past, and now I'm dating a woman, and I see it as ultimately no big deal.”

“There are drawbacks in being famous too, but you can live with those. They're not life-threatening. If the paparazzi are outside your restaurant or your house - and actors make such a big thing of it and scurry into cars and drape things - you think they're going to be crucified or something. It's not a big deal. You can get used to that. It's not so terrible.”

“I learned that you really don't have any control as a writer. Waah, waah, waah. Big deal. Unless you're the director on the movie, or putting up the money for the movie, you really don't have a lot of control. As someone who's just writing scripts, you just kind of have to shrug. I have no problems or issues with screenwriting in general. It is what it is.”

“Tom Stafford was an odd character, you know - a brilliant guy. He looked weird and I think he took a really defensive attitude about being a hunchback. You know how people can be, giving him a hard time. So he turned that into a defensive mechanism. He would strike first, a lot of times. But he was a great guy, and really those talks we had when I was about 15, out of all of that came the studio over the drugstore and everything else. I'm not saying - I'm no big deal, but I was a part of the birth of the music there.”