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“I’m instantly mortified by my fat, uncontrollable mouth, but that’s when it occurs to me that my humor is a self-defense mechanism. Even though I may come off like a stark raving asshat, being funny is the most important tool I have to stay sane. The ability to say what I think is the key to allowing me to feel in control.”

“Whenever we pride ourselves upon finding a newer, stricter way of thought or exposition we lose something of the ability to think new thoughts. And equally, of course, whenever we rebel against the sterile rigidity of formal thought and exposition and let our ideas run wild, we likewise lose. As I see it, the advances in scientific thought come from a combination of lose and strict thinking, and this combination is the most precious tool of science.”

“The ability of human beings to be creative depends fundamentally on the health and well-being of our biosphere, the few kilometres of air, water, and soil that surround our planet like the skin of an apple. Quite simply, they are the physical and spiritual bases of our lives, and the only source of materials and tools.”

“I am dedicating the majority of my wealth to improving education. It is the key to the survival of the human race. We have to plan for our collective future - and the first step begins with the social, emotional, and intellectual tools we provide to our children. As humans, our greatest tool for survival is our ability to think and to adapt - as educators, storytellers, and communicators our responsibility is to continue to do so.”

“The noise you hear after people see something you do - whether it's a TV show or a movie - that always makes you see that thing slightly differently. Without question. The ability of a television series to make adjustments is something you've got to take advantage of. And test-screening a movie can be helpful too. But the part that can be dangerous is when you take those notes as gospel, instead of taking them with a grain of salt. The key is to use the response as one of the tools in your box, as opposed to using it to determine what you do.”

“We cannot deny that our decision today will have an impact on the ability of law enforcement to combat crime. Cell phones have become important tools in facilitating coordination and communication among members of criminal enterprises, and can provide valuable incriminating information about dangerous criminals. Privacy comes at a cost.”

“All designed tools and objects are sort of extensions of human abilities, and they do tend to make life richer for us. But, an awful lot of designs, especially in this country, make life a lot more inconvenient. I'm thinking, for instance, of high-fidelity units that have so many switches and toggles and buttons and things that they confuse most people.”

“Coalition [against ISIS] need the tools. And the tools involve encryption where we cannot hear what they're even planning. And when we see red flags, a father, a mother, a neighbor who says we have got a problem here, then we have to give law enforcement the ability to listen so they can disrupt these terrorist attacks before they occur.”

“What AI could do is essentially be a power tool that magnifies human intelligence and gives us the ability to move our civilization forward. It might be curing disease, it might be eliminating poverty. Certainly it should include preventing environmental catastrophe. If AI could be instrumental to all those things, then I would feel it was worthwhile.”

“I believe the medium of film is one of the most powerful tools in the modern era to create positive social change. It has the ability to put big, complex, and controversial subjects across in an easy-to-understand and digestible form. It has the power to change someone's perspective on the world in a very short space of time - film has the power to change the world itself.”

“What excites me is that, when things are tough, people become resourceful, and now with the Internet, social networking and the ability for people who in the past had been relatively powerless, they have tools to be able to spread ideas and organize. The urgency is there and the tools are there and I think that the possibility for really, really powerful results is there. I think it's all brewing, it's all bubbling up right now.”

“I would say that I have been consistent in my broad view of how American power should be deployed, and the view that we underestimate our power when we restrict it to just our military power. We shortchange our influence and our ability to shape events when that's the only tool we think we have in the toolbox.”

“I think that human beings have gotten as far as we've gotten because of our adaptability, our ability to adapt, and our ability to dovetail our technologies - our brains to our tools. With the Industrial Revolution, we transcended the limits of our muscles. With the digital revolution, we transcend the limits of our minds.”

“The gifts of microscopes to our understanding of cells and organisms is so profound that one has to ask: What are the gifts of the microscopist? Here is my opinion. The gift of the great microscopist is the ability to Think with the eyes and see with the brain. Deep revelations into the nature of living things continue to travel on beams of light.”

“The original PATRIOT Act greatly increased our nation's ability to share intelligence information, made better use of technology, and provided terrorism investigators tools that have long been available in cases involving illegal drugs and organized crime.”

“It must be for truth's sake, and not for the sake of its usefulness to humanity, that the scientific man studies Nature. The application of science to the useful arts requires other abilities, other qualities, other tools than his; and therefore I say that the man of science who follows his studies into their practical application is false to his calling. The practical man stands ever ready to take up the work where the scientific man leaves it, and adapt it to the material wants and uses of daily life.”

“Even if we act immediately, the world is doomed to lose many of its animal and plant species and this inturn will reduce the ability of ecosystems to deliver vital services to human populations. The Red List gives all of us a practical tool for raising awareness of the biodiversity crisis and for forging new partnerships within the international community.”

“Eventually this all passes. The public horrors of today eventually blow away. And, yes, you are changed by the awful wake of reckoning they leave behind. Hopefully in the process you don't lose your ability to throw your arms in the air again and spin in wild abandon. That is the ultimate F.U. and - finally - the most beautiful survival tool of all. Don't let them take that away from you.”