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“But science is the great instrument of social change, all the greater because its object is not change but knowledge, and its silent appropriation of this dominant function, amid the din of political and religious strife, is the most vital of all the revolutions which have marked the development of modern civilisation.”

“I have accumulated a wealth of knowledge in innumerable spheres and enjoyed it as an always ready instrument for exercising the mind and penetrating further and further. Best of all, mine has been a life of loving and being loved. What a tragedy that all this will disappear with the used-up body!”

“While the vaccine discovery was progressive, the joy I felt at the prospect before me of being the instrument destined to take away from the world one of its greatest calamities [smallpox], blended with the fond hope of enjoying independence and domestic peace and happiness, was often so excessive that, in pursuing my favourite subject among the meadows, I have sometimes found myself in a kind of reverie.”

“Men can construct a science with very few instruments, or with very plain instruments; but no one on earth could construct a science with unreliable instruments. A man might work out the whole of mathematics with a handful of pebbles, but not with a handful of clay which was always falling apart into new fragments, and falling together into new combinations. A man might measure heaven and earth with a reed, but not with a growing reed.”

“Actual philosophers... are commanders and law-givers: they say "thus it shall be!", it is they who determine the Wherefore and Whither of mankind, and they possess for this task the preliminary work of all the philosophical laborers, of all those who have subdued the past - they reach for the future with creative hand, and everything that is or has been becomes for them a means, an instrument, a hammer.”

“I repeat the declaration made a year ago, that 'while I remain in my present position I shall not attempt to retract or modify the emancipation proclamation, nor shall I return to slavery any person who is free by the terms of that proclamation, or by any of the Acts of Congress.' If the people should, by whatever mode or means, make it an Executive duty to re-enslave such persons, another, and not I, must be their instrument to perform it.”

“The historian of science may be tempted to claim that when paradigms change, the world itself changes with them. Led by a new paradigm, scientists adopt new instruments and look in new places. even more important, during revolutions, scientists see new and different things when looking with familiar instruments in places they have looked before. It is rather as if the professional community had been suddenly transported to another planet where familiar objects are seen in a different light and are joined by unfamiliar ones as well.”

“The resolution of revolutions is selection by conflict within the scientific community of the fittest way to practice future science. The net result of a sequence of such revolutionary selections, separated by periods of normal research, is the wonderfully adapted set of instruments we call modern scientific knowledge.”

“The more your meditation goes deep, the less and less you will feel the burden of the mind. The more and more meditation goes deep, the less and less you will be a mind. Thoughts will become rare, and ultimately they cease. That doesn't mean you become unthinking; it only means that your consciousness becomes clear, transparent, without thoughts moving continuously as clouds. Whenever you need to think you can think; but now thought becomes an instrument to you, not an obsession as it is presently. Thoughts are an obsession without meditation.”

“The state machine, including the army, the police and the courts, is the instrument with which one class oppresses another. It is an instrument of oppression against all hostile classes; it means violence and is certainly not anything 'benevolent.' 'You are merciless.' Quite so. We definitely do not adopt a benevolent policy towards the reactionary activities of the reactionaries and the reactionary classes.”

“This formidable censor of the public functionaries [the press], by arraigning them at the tribunal of public opinion, produces reform peaceably, which must otherwise be done by revolution. It is also the best instrument for enlightening the mind of man and improving him as a rational, moral, and social being.”

“One correspondent, who is into psychology, notes that in his experience people who are hoplophobes are nearly always nutty in other ways, too. Hoplophobia [fear of guns], of course, is not simply an attitude but rather an aberration in which the sufferer clings to an idea which he himself knows to be unsound, such as the idea that inanimate instruments have a will of their own or that lawbreakers abide by the law.”

“If, in the opinion of the people, the distribution or modification of the constitutional powers be in any particular wrong, let it be corrected by an amendment in the way which the Constitution designates. But let there be no change by usurpation; for though this, in one instance, may be the instrument of good, it is the customary weapon by which free governments are destroyed.”

“The earth has enough knowledge and resources to eradicate this ancient scourge. Hunger has plagued the world for thousands of years. But ending it is a greater moral imperative now than ever before, because for the first time humanity has the instruments at hand to defeat this cruel enemy at a very reasonable cost. We have the ability to provide food for all within the next three decades.”

“The brain is not, like the liver, heart and other internal organs, capable from the moment of birth of all the functions which it ever discharges; for while in common with them, it has certain duties for the exercise of which it is especially intended, its high character in man, as the organ of conscious life, the supreme instrument of his relations with the rest of nature, is developed only by a long and patient training.”

“Reason is not one tool of thought among many, it is the entire toolbox. To advocate that reason be discarded in some circumstances is to advocate that thinking be discarded - which leaves one in the position of attempting to do a job after throwing away the required instrument.”

“For those [observations] that I made in Leipzig in my youth and up to my 21st year, I usually call childish and of doubtful value. Those that I took later until my 28th year [i.e., until 1574] I call juvenile and fairly serviceable. The third group, however, which I made at Uraniborg during approximately the last 21 years with the greatest care and with very accurate instruments at a more mature age, until I was fifty years of age, those I call the observations of my manhood, completely valid and absolutely certain, and this is my opinion of them.”

“O marvelous Sacrament! How can I find words to praise you! You are the life of the soul, the medicament healing our wounds, our comforter when we are overburdened, the memorial of Jesus Christ, the proof of his love, the most precious precept of his testament, our companion in the pilgrimage of life, the joy sustaining us in our exile, the burning coal kindling the fire of divine love, the instrument of grace, the pledge of eternal bliss and the treasure of Christians”

“Then very slowly I go to slightly lighter colors until little by little, the forms begin to take shape and I start to see what is happening. Since I never plan in advance, I simply let myself be led by instinct, taste and intuition. And it is in this manner that I find myself creating visions that I have never before imagined. And little by little certain color effects develop that excite me and I find the painting itself leading me on and I become only an instrument of a greater, wiser force...or being...or intelligence than I myself am.”

“Technology and production can be great benefactors of man, but they are mindless instruments, and if undirected they careen along with a momentum of their own. In our country, they pulverize everything in their path - the landscape, the natural environment.”

“Government is about coercion. Limiting government is the single most important instrument for guaranteeing liberty. We're working on a third generation which has little in the way of education about what our Constitution means and why it was written. Thus, we've fallen easy prey to charlatens, quacks, and hustlers.”

“The day when the scientist, no matter how devoted, may make significant progress alone and without material help is past. This fact is most self-evident in our work. Instead of an attic with a few test tubes, bits of wire and odds and ends, the attack on the atomic nucleus has required the development and construction of great instruments on an engineering scale.”

“The science and technology which have advanced man safely into space have brought about startling medical advances for man on earth. Out of space research have come new knowledge, techniques and instruments which have enabled some bedridden invalids to walk, the totally deaf to hear, the voiceless to talk, and, in the foreseeable future, may even make it possible for the blind to "see."”

“From the point of view of the pure morphologist the recapitulation theory is an instrument of research enabling him to reconstruct probable lines of descent; from the standpoint of the student of development and heredity the fact of recapitulation is a difficult problem whose solution would perhaps give the key to a true understanding of the real nature of heredity.”

“[The infinitely small] neither have nor can have theory; it is a dangerous instrument in the hands of beginners [ ... ] anticipating, for my part, the judgement of posterity, I would dare predict that this method will be accused one day, and rightly, of having retarded the progress of the mathematical sciences.”

“He was Caesar and Pope in o­ne; but he was Pope without Pope's pretensions, Caesar without the legions of Caesar: without a standing army, without a bodyguard, without a palace, without a fixed revenue; if ever any man had the right to say that he ruled by the right divine, it was Mohammed, for he had all the power without its instruments and without its supports.”

“During the reign of Rameses III (the Twentieth Dynasty) Egypt saw a flowering of its civilization and the harp became the royal instrument of priests and kings. Often times they had as many as 21 strings. Under the manipulation "the Minstrels of the Gods" the music was of rare potency. "Musical Medicine" was an actuality. Healing, along with numerous so-called "supernatural feats" was attributed to this art.”

“Consciousness is somehow a by-product of the simultaneous, high frequency firing of neurons in different parts of the brain. It's the meshing of these frequencies that generates consciousness, just as tones from individual instruments produce the rich, complex, & seamless sounds of a symphony orchestra”

“O most sacred, most loving heart of Jesus, thou art concealed in the Holy Eucharist, and thou beatest for us still.... Thou art the heart of the Most High made man.... Thy Sacred Heart is the instrument and organ of Thy love. It did beat for us. It yearned for us. It ached for our salvation. It was on fire through zeal, that the glory of God might be manifested in and by us.... In worshipping thee I worship my incarnate God, my Emmanuel”

“We have taken so much from your culture, I wish you had taken something from ours...For there were some beautiful and good things within it. Perhaps now that the time has come, We are fearful that what you take will be lost.... I shall grab the instruments of the white man's success: His education, his skills, and society.”