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“[John] Dalton was a man of regular habits. For fifty-seven years he walked out of Manchester every day; he measured the rainfall, the temperature-a singularly monotonous enterprise in this climate. Of all that mass of data, nothing whatever came. But of the one searching, almost childlike question about the weights that enter the construction of these simple molecules-out of that came modern atomic theory. That is the essence of science: ask an impertinent question, and you are on the way to the pertinent answer.”

“How then did we come to the "standard model"? And how has it supplanted other theories, like the steady state model? It is a tribute to the essential objectivity of modern astrophysics that this consensus has been brought about, not by shifts in philosophical preference or by the influence of astrophysical mandarins, but by the pressure of empirical data.”

“We are ... led to a somewhat vague distinction between what we may call "hard" data and "soft" data. This distinction is a matter of degree, and must not be pressed; but if not taken too seriously it may help to make the situation clear. I mean by "hard" data those which resist the solvent influence of critical reflection, and by "soft" data those which, under the operation of this process, become to our minds more or less doubtful.”

“Mathematics may be compared to a mill of exquisite workmanship, which grinds you stuff of any degree of fineness; but, nevertheless, what you get out depends upon what you put in; and as the grandest mill in the world will not extract wheat-flour from peascods, so pages of formulae will not get a definite result out of loose data.”

“The study of theology, as it stands in Christian churches, is the study of nothing; it is founded on nothing; it rests on no principles; it proceeds by no authorities; it has no data; it can demonstrate nothing; and it admits of no conclusion.”

“Lately we have been getting facts pointing to the "oceanic" nature of the floor of so-called inland seas. Through geological investigations it has been definitely established that in its deepest places, for instance, the Caribbean Sea and the Gulf of Mexico, the Earth's crust is devoid of granite stratum. The same may be said quite confidently about the Mediterranean and the Black Sea. Could the interpretation of these data be that inland seas were the primary stage of the formation of oceanic basins?”

“[In research on bacteria metabolism] we have indeed much the same position as an observer trying to gain an idea of the life of a household by careful scrutiny of the persons and material arriving or leaving the house; we keep accurate records of the foods and commodities left at the door and patiently examine the contents of the dust-bin and endeavour to deduce from such data the events occurring within the closed doors.”

“The mechanist is intimately convinced that a precise knowledge of the chemical constitution, structure, and properties of the various organelles of a cell will solve biological problems. This will come in a few centuries. For the time being, the biologist has to face such concepts as orienting forces or morphogenetic fields. Owing to the scarcity of chemical data and to the complexity of life, and despite the progresses of biochemistry, the biologist is still threatened with vertigo.”

“Measurement has too often been the leitmotif of many investigations rather than the experimental examination of hypotheses. Mounds of data are collected, which are statistically decorous and methodologically unimpeachable, but conclusions are often trivial and rarely useful in decision making. This results from an overly rigorous control of an insignificant variable and a widespread deficiency in the framing of pertinent questions. Investigators seem to have settled for what is measurable instead of measuring what they would really like to know.”

“[Theory is] an explanation that has been confirmed to such a degree, by observation and experiment, that knowledgeable experts accept it as fact. That's what scientists mean when they talk about a theory: not a dreamy and unreliable speculation, but an explanatory statement that fits the evidence. They embrace such an explanation confidently but provisionally - taking it as their best available view of reality, at least unil some severely conflicting data or some better explanation might come along.”

“The investigation of causal relations between economic phenomena presents many problems of peculiar difficulty, and offers many opportunities for fallacious conclusions. Since the statistician can seldom or never make experiments for himself, he has to accept the data of daily experience, and discuss as best he can the relations of a whole group of changes; he cannot, like the physicist, narrow down the issue to the effect of one variation at a time. The problems of statistics are in this sense far more complex than the problems of physics.”

“While, on the one hand, the end of scientific investigation is the discovery of laws, on the other, science will have reached its highest goal when it shall have reduced ultimate laws to one or two, the necessity of which lies outside the sphere of our cognition. These ultimate laws-in the domain of physical science at least-will be the dynamical laws of the relations of matter to number, space, and time. The ultimate data will be number, matter, space, and time themselves. When these relations shall be known, all physical phenomena will be a branch of pure mathematics.”

“Perhaps generations of students of human evolution, including myself, have been flailing about in the dark; that our data base is too sparse, too slippery, for it to be able to mold our theories. Rather the theories are more statements about us and ideology than about the past. Paleontology reveals more about how humans view themselves than it does about how humans came about, but that is heresy.”

“Paleontologists [fossil experts] have paid an exorbitant price for Darwin's argument. We fancy ourselves as the only true students of life's history, yet to preserve our favored account of evolution by natural selection we view our data as so bad that we almost never see the very process we profess to study.”

“If you intend to study the mind, you must have systematic training; you must practice to bring the mind under your control, to attain to that consciousness from which you will be able to study the mind and remain unmoved by any of its wild gyrations. Otherwise the facts observed will not be reliable; they will not apply to all people and therefore will not be truly facts or data at all.”

“The fact that all normal children acquire essentially comparable grammars of great complexity with remarkable rapidity suggests that human beings are somehow specially designed to do this, with data-handling or 'hypothesis-formulating' ability of unknown character and complexity.”

“The World Health Organization recently published some data showing that each overweight person causes and additional one tonne of CO2 to be emitted every year. With one billion people overweight around the world-of whom at least 300 million are obese-that's an additional one billion tonnes.”

“These data suggest very strongly that participating in the playing of violent video games by children and youth increase aggressive thought and behavior; increase antisocial behavior and delinquency; engender poor school performance; desensitize the game player to violence.”